CryoStim™ is a novel in-situ therapeutic cancer vaccine for patients with disseminated metastatic tumors. CryoStim™ combines AlloStim™ with cryosurgical ablation of a single tumor, stimulating a tumor-specific immune response which eliminates tumors wherever they are located through-out the body. Patients are first infused with a dose of AlloStim™. The rejection of the allogeneic mis-matched AlloStim™ cells results in the patient being immune to the drug. Immune patients then undergo a procedure to freeze an accessible tumor. This causes the tumor to die by a process of necrosis, a pathological mechanism that results in an immune response to clean-up and repair the damaged tissue. Additional AlloStim™ is injected into the necrotic tumor lesion resulting in a memory recall immune response to reject the allogeneic cells. The combination of these two powerful immune responses results in the education of the immune system to perceive the dead tumor tissue as a danger.


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